目的 研究广东紫珠叶乙酸乙酯部位的化学成分。方法 利用硅胶、Sephadex LH-20、ODS、MPLC等柱色谱方法进行化合物的分离纯化,根据化合物的理化性质、波谱方法进行结构鉴定。结果 从广东紫珠叶乙酸乙酯部位分离得到13个化合物,分别为:5,7,2′,6′-四羟基黄酮(1)、2,3-dehydrosilychristin(2)、silychristin A(3)、二氢槲皮素(4)、丁香脂素(5)、杜仲树脂酚(6)、(7R,8S)-3,5′-dimethoxy-4′,7-epoxy-8,3′-neolignane-5,9,9′-triol(7)、(2S,3R)-methyl-7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-2,3-dihydrobenzofuran-5-carboxylate(8)、curcasinlignan B(9)、香草醛(10)、19α-羟基熊果酸(11)、2α,3β,19α,23-四羟基-齐墩果-12-烯-28-酸(12)和蔷薇酸(13)。结论 以上化合物均为首次从广东紫珠中分离得到。
Abstract
OBJECTIVE To study the chemical ethyl acetate-soluble constituents of the leaves of Callicarpa kwangtungensis Chun. METHODS The compounds were isolated and purified by column chromatography using silica gel, Sephadex LH-20, ODS and MPLC. The structures of the compounds were identified according to their physicochemical properties and spectroscopic methods. RESULTS Thirteen compounds were isolated and identified as 5,7,2′,6′-tetrahydroxyflavone(1), 2,3-dehydrosilychristin(2), silychristin A(3), dihydroquercetin(4), syringaresinol(5), medioresinol(6),(7R,8S)-3,5′-dimethoxy-4′,7-epoxy-8,3′-neolignane -5,9,9′-triol(7),(2S,3R)-methyl-7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-2,3-dihydrobenzofuran-5-carboxylate(8), curcasinlignan B(9), vanillin(10), 19α-hydroxyursolic acid(11), 2α,3β,19α,23-tetrahydroxy-12-ene-28-oleanolic acid(12), and euscaphic acid(13). CONCLUSION All these compounds were isolated from this plant for the first time.
关键词
广东紫珠 /
马鞭草科 /
5 /
7 /
2′ /
6′-四羟基黄酮 /
二氢槲皮素
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Key words
Callicarpa kwangtungensis Chun /
verbenaceae /
5,7,2′,6′-tetrahydroxyflavone /
dihydroquercetin
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中图分类号：
R284
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脚注
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基金
国家自然科学基金项目资助(81460589)
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